Fmoc-Lys-OH (hydrochloride)

Fmoc-Lys-OH hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Fmoc-Lys-OH hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

Product Specifications

CAS Number

[139262-23-0]

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fmoc-lys-oh-hydrochloride.html

Purity

99.84

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

NCCCC[C@H](NC(OCC1C2=CC=CC=C2C3=CC=CC=C13)=O)C(O)=O.Cl

Molecular Formula

C21H25ClN2O4

Molecular Weight

404.89

Precautions

H302, H315, H319, H335

References & Citations

[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16 (5) :315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.