Custirsen (sodium)

Custirsen sodium is a highly specific antisense oligonucleotide that inhibits the production of clusterin , an antiapoptotic protein that is upregulated in response to chemotherapy and that confers treatment resistance.

Product Specifications

Product Name Alternative

OGX-011 (sodium)

UNSPSC

12352208

Target

Apoptosis

Type

Oligonucleotides

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/custirsen-sodium.html

Purity

96.06

Solubility

10 mM in H2O

Smiles

[Custirsen(sodium)]

Molecular Formula

C231H292N78Na20O119P20S20

Molecular Weight

7346 (free acid)

References & Citations

[1]Chi KN, Eisenhauer E, Fazli L, et al. A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2'-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer. J Natl Cancer Inst. 2005;97 (17) :1287-1296.