Guanethidine

Guanethidine sulphate was synthesized in 1959. Guanethidine is thought to lowing blood pressure by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres.

Product Specifications

CAS Number

[55-65-2]

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/guanethidine.html

Solubility

10 mM in DMSO

Smiles

NC(NCCN1CCCCCCC1)=N

Molecular Formula

C10H22N4

Molecular Weight

198.31

References & Citations

[1]P Dubový, etal. Local chemical sympathectomy of rat bone marrow and its effect on marrow cell composition.|[2]Waldiceu A.VerriJr, etal. Antigen-induced inflammatory mechanical hypernociception in mice is mediated by IL-18. Brain Beha