Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Pronethalol (hydrochloride)

Pronethalol ((±) -Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs) [1][2].

Product Specifications

CAS Number

51-02-5

Product Name Alternative

(±) -Pronethalo (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pronethalol-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

OC(CNC(C)C)C1=CC=C2C=CC=CC2=C1.Cl

Molecular Formula

C15H20ClNO

Molecular Weight

265.78

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Jiayi Yao, et al. Elevated endothelial Sox2 causes lumen disruption and cerebral arteriovenous malformations. J Clin Invest. 2019 Jun 24;129 (8) :3121-3133.|[2]Aroesty JM, et al. The effects of a beta-adrenergic blocking agent, pronethalol, on digitalis-induced ventricular arrhythmias. Am Heart J. 1966 Apr;71 (4) :503-508.|[3]Aroesty JM, et al. The effects of a beta-adrenergic blocking agent, pronethalol, on digitalis-induced ventricular arrhythmias. Am Heart J. 1966 Apr;71 (4) :503-8.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

β adrenergic receptor

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Recombinant MGST3 Antibody
RC-5195-01 50 μL

Recombinant MGST3 Antibody

Sign In for Pricing
View Details
Recombinant MGST3 Antibody
RC-5195-02 100 µL

Recombinant MGST3 Antibody

Sign In for Pricing
View Details
Recombinant MGST3 Antibody
RC-5195-03 1 mL

Recombinant MGST3 Antibody

Sign In for Pricing
View Details
Frozen Tissue Sections, Kidney
CS628530 5x 5 µm

Frozen Tissue Sections, Kidney

Sign In for Pricing
View Details
3-Aminopiperidin-2-one Hydrochloride
TRC-A632983-10MG 10 mg

3-Aminopiperidin-2-one Hydrochloride

Sign In for Pricing
View Details
SOX4 (Master Regulator of Epithelial-Mesenchymal Transition) (SOX4/2540), CF640R conjugate, 0.1mg/mL
BNC402540-500 1x 500 µL

SOX4 (Master Regulator of Epithelial-Mesenchymal Transition) (SOX4/2540), CF640R conjugate, 0.1mg/mL

Sign In for Pricing
View Details