R- (+) -Cotinine
R- (+) -Cotinine ((+) -Cotinine), a Nicotine metabolite, lacks significant activity across a wide range of pharmacological targets. R- (+) -Cotinine can enhance the Ach-evoked current in human α7 nAChRs[1].
Product Specifications
CAS Number
[32162-64-4]
Product Name Alternative
(+) -Cotinine; (R) -Cotinine; (R) -NIH-10498
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/r-plus-cotinine.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C)[C@@H](C2=CC=CN=C2)CC1
Molecular Formula
C10H12N2O
Molecular Weight
176.22
References & Citations
[1]Jr AVT, et, al. R- (+) and S- (-) isomers of cotinine augment cholinergic responses in vitro and in vivo. J Pharmacol Exp Ther. 2015 Feb;352 (2) :405-18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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