R- (+) -Cotinine

R- (+) -Cotinine ((+) -Cotinine), a Nicotine metabolite, lacks significant activity across a wide range of pharmacological targets. R- (+) -Cotinine can enhance the Ach-evoked current in human α7 nAChRs[1].

Product Specifications

CAS Number

[32162-64-4]

Product Name Alternative

(+) -Cotinine; (R) -Cotinine; (R) -NIH-10498

UNSPSC

12352005

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/r-plus-cotinine.html

Solubility

10 mM in DMSO

Smiles

O=C1N(C)[C@@H](C2=CC=CN=C2)CC1

Molecular Formula

C10H12N2O

Molecular Weight

176.22

References & Citations

[1]Jr AVT, et, al. R- (+) and S- (-) isomers of cotinine augment cholinergic responses in vitro and in vivo. J Pharmacol Exp Ther. 2015 Feb;352 (2) :405-18.