Chlorhexidine-d8 (dihydrochloride)

Chlorhexidine-d8 (dihydrochloride) is the deuterium labeled Chlorhexidine dihydrochloride (HY-B1145) . Chlorhexidine dihydrochloride is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine dihydrochloride binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine dihydrochloride has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine dihydrochloride can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis) [1][2][3].

Product Specifications

CAS Number

[2012598-75-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Apoptosis; Bacterial; Isotope-Labeled Compounds; Necroptosis

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Apoptosis; Others

Field of Research

Infection

Purity

95.70

Solubility

10 mM in DMSO

Smiles

ClC(C([2H])=C1[2H])=C([2H])C([2H])=C1NC(NC(NCCCCCCNC(NC(NC2=C([2H])C([2H])=C(C([2H])=C2[2H])Cl)=N)=N)=N)=N.Cl.Cl

Molecular Formula

C22H24D8Cl4N10

Molecular Weight

586.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-236.|[2]Faria G, et al. Evaluation of chlorhexidine toxicity injected in the paw of mice and added to cultured l929 fibroblasts. J Endod. 2007 Jun;33 (6) :715-22.|[3]Zhang J, et al. Pulmonary Toxicity Assessment after a Single Intratracheal Inhalation of Chlorhexidine Aerosol in Mice. Toxics. 2023 Nov 7;11 (11) :910.|[4]Sanchez IR, et al. Chlorhexidine diacetate and povidone-iodine cytotoxicity to canine embryonic fibroblasts and Staphylococcus aureus. Vet Surg. 1988;17 (4) :182-185.|[5]Ribeiro DA, et al. Chlorhexidine induces DNA damage in rat peripheral leukocytes and oral mucosal cells. J Periodontal Res. 2004 Oct;39 (5) :358-61.