Imazalil (sulfate)

Imazalil (Enilconazole) sulfate is a fungicide. Imazalil sulfate has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil sulfate is commonly used to protect various agricultural crops against fungal attack. Imazalil sulfate induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder[1][2][3].

Product Specifications

CAS Number

[58594-72-2]

Product Name Alternative

Enilconazolel (sulfate)

UNSPSC

12352005

Hazard Statement

H302, H317, H318, H351, H373, H410

Target

Fungal; Pregnane X Receptor (PXR)

Type

Reference compound

Related Pathways

Anti-infection; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/imazalil-sulfate.html

Concentration

10mM

Purity

99.63

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

C=CCOC(C1=CC=C(Cl)C=C1Cl)CN2C=CN=C2.O=S(O)(O)=O

Molecular Formula

C14H16Cl2N2O5S

Molecular Weight

395.26

Precautions

H302, H317, H318, H351, H373, H410

References & Citations

[1]Hiroyuki Kojima, et al. Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ. Toxicol Appl Pharmacol. 2012 Mar 15;259 (3) :338-45.|[2]Shohei Yoshimaru, et al. Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR. J Toxicol Sci. 2018;43 (7) :443-450.|[3]Cuiyuan Jin, et al. Chronic exposure of mice to low doses of imazalil induces hepatotoxicity at the physiological, biochemical, and transcriptomic levels. Environ Toxicol. 2018 Jun;33 (6) :650-658.