Antazoline
Antazoline (Phenazoline) is a histamine H1 receptor antagonist with anticholinergic and antiviral properties. Antazoline can prevent histamine from acting on target cells through a reversible competition effect on histamine receptor sites of these cells. Antazoline can exert an antiallegic effect and prevent the occurrence of physiological reactions from the effect of blocking as well as inhibiting H1 receptor. Antazoline can effectively reduce HBV DNA in the extracellular supernatant in a dose-dependent manner, with EC50 of 2.910 μmol/L in HepAD38 cells. Antazoline also has a significant inhibitory effect on HBV DNA in the extracellular supernatant of Huh7 cells (EC50 = 2.349 μmol/L) . Antazoline has anti-arrhythmic effect in acute myocardial infarctions. Antazoline can be studied in research for cardiovascular diseases, and HBV[1][2][3].
Product Specifications
CAS Number
[91-75-8]
Product Name Alternative
Phenazoline
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Endocrinology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/antazoline.html
Purity
99.70
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C1(CN(C2=CC=CC=C2)CC3=CC=CC=C3)=NCCN1
Molecular Formula
C17H19N3
Molecular Weight
265.35
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B1067A/Antazoline-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B1067A/Antazoline-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
H1 Receptor
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