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Benfluorex

Benfluorex (JP-992) is a hepatic nuclear factor 4 alpha (HNF4α) activator.

Product Specifications

CAS Number

23602-78-0

Product Name Alternative

JP-992

UNSPSC

12352005

Target

Orphan Nuclear Receptor; Orphan Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Benfluorex.html

Solubility

10 mM in DMSO

Smiles

FC(C1=CC(CC(NCCOC(C2=CC=CC=C2)=O)C)=CC=C1)(F)F

Molecular Formula

C19H20F3NO2

Molecular Weight

351.36

References & Citations

[1]Lee SH, et al. Identification of alverine and benfluorex as HNF4α activators. ACS Chem Biol. 2013 Aug 16;8 (8) :1730-6.|[2]Kohl C, et al. Effects of benfluorex on fatty acid and glucose metabolism in isolated rat hepatocytes: from metabolic fluxes to gene expression. Diabetes. 2002 Aug;51 (8) :2363-8.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Biochem Pharmacol. 2022 Sep:203:115198.|EBioMedicine. 2022 Aug:82:104181.|Research Square Print. December 19th, 2022.|Adv Sci (Weinh) . 2024 Jul 5:e2403451.|Virol J. 2021 Sep 28;18 (1) :196.

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