Ambroxol-d5 (hydrochloride)

Ambroxol-d5 (hydrochloride) is the deuterium labeled Ambroxol hydrochloride. Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research[1][2].

Product Specifications

CAS Number

[2741380-71-0]

Product Name Alternative

NA-872-d5 (hydrochloride)

UNSPSC

12352005

Target

Autophagy; Glycosidase; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Others

Field of Research

Metabolic Disease; Neurological Disease

Purity

99.61

Solubility

10 mM in DMSO|DMF : ≥ 20mg/mL|DMSO : ≥ 20mg/mL

Smiles

O[C@@](C([2H])([2H])C1)([2H])C([2H])([2H])C[C@@H]1NCC2=C(C(Br)=CC(Br)=C2)N.Cl

Molecular Formula

C13H14D5Br2ClN2O

Molecular Weight

419.59

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Vojo Deretic, et al. Enhancement of lung levels of antibiotics by ambroxol and bromhexine. Expert Opin Drug Metab Toxicol. 2019 Mar;15 (3) :213-218.|[3]Anna Migdalska-Richards, et al. Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. Ann Neurol. 2016 Nov;80 (5) :766-775.