Oxyphencyclimine
Oxyphencyclimine is an orally active muscarinic receptor (mAChR) antagonist. Oxyphencyclimine is effective in reducing ulceration index and increasing pepsin activity in rat gastric ulcer model. Oxyphencyclimine can be used in studies of peptic ulcer disease and gastrointestinal spasm[1][2].
Product Specifications
CAS Number
125-53-1
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/oxyphencyclimine.html
Solubility
10 mM in DMSO
Smiles
O=C(C(C1=CC=CC=C1)(C2CCCCC2)O)OCC3=NCCCN3C
Molecular Formula
C20H28N2O3
Molecular Weight
344.45
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Coppi G, et al. Experimental gastric ulcers and stomach tissue pepsin activity in the rat. J Pharm Pharmacol. 1972 Apr;24 (4) :332-3. |[2]Waelbroeck M, et al. Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and oxyphencyclimine, and of related antagonists, with four muscarinic receptors. Eur J Pharmacol. 1992 Sep 1;227 (1) :33-42.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
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