Oxyphencyclimine

Oxyphencyclimine is an orally active muscarinic receptor (mAChR) antagonist. Oxyphencyclimine is effective in reducing ulceration index and increasing pepsin activity in rat gastric ulcer model. Oxyphencyclimine can be used in studies of peptic ulcer disease and gastrointestinal spasm[1][2].

Product Specifications

CAS Number

[125-53-1]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/oxyphencyclimine.html

Solubility

10 mM in DMSO

Smiles

O=C(C(C1=CC=CC=C1)(C2CCCCC2)O)OCC3=NCCCN3C

Molecular Formula

C20H28N2O3

Molecular Weight

344.45

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Coppi G, et al. Experimental gastric ulcers and stomach tissue pepsin activity in the rat. J Pharm Pharmacol. 1972 Apr;24 (4) :332-3. |[2]Waelbroeck M, et al. Stereoselective interaction of procyclidine, hexahydro-difenidol, hexbutinol and oxyphencyclimine, and of related antagonists, with four muscarinic receptors. Eur J Pharmacol. 1992 Sep 1;227 (1) :33-42.