Tilmicosin-d3

Tilmicosin-d3 is the deuterium labeled Tilmicosin. Tilmicosin (LY-177370) is an orally active calcium channel antagonist and macrolide antibiotic with antimicrobial activity. Tilmicosin mainly acts on the 50S subunit of bacterial ribosomes, inhibiting protein synthesis. Tilmicosin is effective in the treatment of respiratory diseases in livestock such as cattle, sheep and pigs. In addition, Tilmicosin has immunomodulatory and anti-inflammatory effects[1][2].

Product Specifications

CAS Number

[2714486-61-8]

Product Name Alternative

LY-177370-d3; EL-870-d3

UNSPSC

12352005

Hazard Statement

H315, H317, H319, H334, H335, H410

Target

Antibiotic; Apoptosis; Bacterial; COX; Isotope-Labeled Compounds; NO Synthase

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; Others

Field of Research

Infection; Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

C[C@@H]([C@@H](CC1=O)O)[C@H]([C@H](C[C@H](C(/C=C/C(C)=C/[C@H](CO[C@H](O[C@H](C)[C@@H](O)[C@H]2OC)[C@@H]2OC)[C@@H](CC)O1)=O)C)CCN(C[C@H](C)C3)C[C@H]3C)O[C@@](O[C@H](C)[C@@H](O)[C@@H]4N(C)C([2H])([2H])[2H])([H])[C@@H]4O

Molecular Formula

C46H77D3N2O13

Molecular Weight

872.15

Precautions

H315, H317, H319, H334, H335, H410

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Micotil 300 New Animal Drug Application