Fomepizole (hydrochloride)

Fomepizole (4-Methylpyrazole) hydrochloride is a potent and orally active cytochrome P450 (CYP2E1) inhibitor. Fomepizole hydrochloride is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole hydrochloride blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole hydrochloride has the potential for an antidote for ethylene glycol or methanol poisoning[1][2][3].

Product Specifications

CAS Number

[56010-88-9]

Product Name Alternative

4-Methylpyrazole (hydrochloride)

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/fomepizole-hydrochloride.html

Concentration

10mM

Purity

99.85

Solubility

DMSO : 350 mg/mL (ultrasonic) |H2O : 350 mg/mL (ultrasonic)

Smiles

CC1=CNN=C1.[H]Cl

Molecular Formula

C4H7ClN2

Molecular Weight

118.56

Precautions

H315, H319, H335

References & Citations

[4]Páez AM, et al. Effects of 4-methylpyrazole on ethanol neurobehavioral toxicity in CD-1 mice. Acad Emerg Med. 2004 Aug;11 (8) :820-6. |[1]Casavant MJ. Fomepizole in the treatment of poisoning. Pediatrics. 2001 Jan;107 (1) :170.|[2]Lepik KJ, et al. Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning: a comparison of ethanol and fomepizole. Ann Emerg Med. 2009 Apr;53 (4) :439-450.e10.|[3]Garrett Rampon, et al. Use of fomepizole as an adjunct in the treatment of acetaminophen overdose: a case series. Toxicology Communications. Volume 4, 2020 - Issue 1.