Tebuconazole-d9
Tebuconazole-d9 is the deuterium labeled Tebuconazole. Tebuconazole is an agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively.
Product Specifications
CAS Number
1246818-83-6
UNSPSC
12352005
Hazard Statement
H302-H361-H411
Target
Cytochrome P450; Fungal
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Solubility
10 mM in DMSO
Smiles
OC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])(CCC1=CC=C(Cl)C=C1)CN2C=NC=N2
Molecular Formula
C16H13D9ClN3O
Molecular Weight
316.87
Precautions
P264-P270-P273-P280-P330-P391-P405-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Warrilow AG, et al. Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens. Antimicrob Agents Chemother. 2013 Mar;57 (3) :1352-60.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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