Tebuconazole-d9
Product Specifications
UNSPSC Description
Tebuconazole-d9 is the deuterium labeled Tebuconazole. Tebuconazole is an agricultural azole fungicide which can also inhibit CYP51 with IC50s of 0.9 and 1.3 μM for Candida albicans CYP51 (CaCYP51) and truncated Homo sapiens CYP51 (Δ60HsCYP51), respectively.
Target Antigen
Cytochrome P450; Fungal
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection;Metabolic Enzyme/Protease
Field of Research
Infection
Solubility
10 mM in DMSO
Smiles
OC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])(CCC1=CC=C(Cl)C=C1)CN2C=NC=N2
Molecular Weight
316.87
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Warrilow AG, et al. Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens. Antimicrob Agents Chemother. 2013 Mar;57(3):1352-60.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
CAS Number
1246818-83-6
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