Propiconazole-d3 (nitrate)
Propiconazole-d3 (nitrate) is the deuterium labeled Propiconazole nitrate. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 µM, respectively) . Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 µg/mL, respectively) . Propiconazole increases production of reactive oxygen species (ROS) .
Product Specifications
CAS Number
2699607-26-4
UNSPSC
12352005
Hazard Statement
H302-H317-H360
Target
Fungal; Isotope-Labeled Compounds; Reactive Oxygen Species (ROS)
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others
Field of Research
Infection
Solubility
10 mM in DMSO
Smiles
ClC1=CC(Cl)=C(C2(OC([2H])(C([2H])(O2)CCC)[2H])CN3C=NC=N3)C=C1.O=[N+]([O-])O
Molecular Formula
C15H15D3Cl2N4O5
Molecular Weight
408.25
Precautions
P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P405-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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