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Propiconazole-d7

Propiconazole-d7 is the deuterium labeled Propiconazole. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 μM, respectively) . Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 μg/mL, respectively) . Propiconazole increases production of reactive oxygen species (ROS) [1].

Product Specifications

CAS Number

1246818-14-3

UNSPSC

12352005

Hazard Statement

H301-H312-H330-H410

Target

Fungal; Isotope-Labeled Compounds; Reactive Oxygen Species (ROS)

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Solubility

10 mM in DMSO

Smiles

C(C1(OC(C(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H])CO1)C2=C(Cl)C=C(Cl)C=C2)N3C=NC=N3

Molecular Formula

C15H10D7Cl2N3O2

Molecular Weight

349.26

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]Teng M, et al. Effect of Propiconazole on the Lipid Metabolism of Zebrafish Embryos (Danio rerio) . J Agric Food Chem. 2019;67 (16) :4623-4631.|[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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