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Metalaxyl-M-d6

Metalaxyl-M-d6 ((R) -Metalaxyl-d6) is the deuterium labeled Metalaxyl-M. Metalaxyl-M ((R) -Metalaxyl) is an orally active and selective inhibitor of fungal RNA polymerase, which exerts fungicidal activity by selectively interfering with the synthesis of fungal ribosomal RNA. Metalaxyl-M can also be used to induce inflammation in hepatocytes and regulate tryptophan metabolism. Metalaxyl-M can be used in ecotoxicology studies[1][2][3].

Product Specifications

CAS Number

1398112-32-7

UNSPSC

12352005

Target

DNA/RNA Synthesis; Fungal; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

COC([C@@H](C)N(C1=C(C=CC=C1C([2H])([2H])[2H])C([2H])([2H])[2H])C(COC)=O)=O

Molecular Formula

C15H15D6NO4

Molecular Weight

285.37

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Yinjun Zhang, et al. Bio-preparation of (R) -DMPM using whole cells of Pseudochrobactrum asaccharolyticum WZZ003 and its application on kilogram-scale synthesis of fungicide (R) -metalaxyl. Biotechnol Prog|[3]OuYang MN, et al. The different toxic effects of metalaxyl and metalaxyl-M on Tubifex tubifex. Ecotoxicol Environ Saf. 2021 Jan 15;208:111587.|[4]Zhang P, et al. Identifying Metabolic Perturbations and Toxic Effects of Rac-Metalaxyl and Metalaxyl-M in Mice Using Integrative NMR and UPLC-MS/MS Based Metabolomics. Int J Mol Sci. 2019 Nov 1;20 (21) :5457.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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