Theophylline (monohydrate)

Theophylline (1,3-Dimethylxanthine) monohydrate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) monohydrate inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) monohydrate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) monohydrate induces apoptosis. Theophylline (1,3-Dimethylxanthine) monohydrate can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5].

Product Specifications

CAS Number

[5967-84-0]

Product Name Alternative

1,3-Dimethylxanthine (monohydrate) ; Theo-24 (monohydrate)

UNSPSC

12352005

Hazard Statement

H301, H311, H330

Target

Adenosine Receptor; Apoptosis; Endogenous Metabolite; HDAC; Interleukin Related; Phosphodiesterase (PDE) ; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/theophylline-monohydrate.html

Purity

99.85

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(N(C)C(N1C)=O)N=CN2.O

Molecular Formula

C7H10N4O3

Molecular Weight

198.18

Precautions

H301, H311, H330

References & Citations

[1]Rabe KF, et, al. Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants. Eur Respir J. 1995 Apr;8 (4) :637-42.|[2]Chung IY, et, al. The downregulation of Bcl-2 expression is necessary for theophylline-induced apoptosis of eosinophil. Cell Immunol. 2000 Aug 1;203 (2) :95-102.|[3]Ichiyama T, et, al. Theophylline inhibits NF-kappa B activation and I kappa B alpha degradation in human pulmonary epithelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2001 Dec;364 (6) :558-61.|[4]Ito K, et, al, Adcock IM, Barnes PJ. A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S A. 2002 Jun 25;99 (13) :8921-6.|[5]Barnes PJ. Theophylline. Am J Respir Crit Care Med. 2013 Oct 15;188 (8) :901-6.