AZ7550-d5
AZ7550-d5 is the deuterium labeled AZ7550?. AZ7550, an active metabolite of Osimtinib (AZD9291; HY-15772), inhibits the activity of?IGF1R?with an?IC50?of 1.6 μM[1][2].
Product Specifications
CAS Number
2719690-99-8
UNSPSC
12352005
Target
Drug Metabolite; EGFR; IGF-1R
Type
Isotope-Labeled Compounds
Related Pathways
JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC(NC2=NC=CC(C3=CN(C([2H])([2H])[2H])C4=C3C=CC=C4)=N2)=C(OC)C=C1N(C)CCNC)/C=C([2H])\[2H]
Molecular Formula
C27H26D5N7O2
Molecular Weight
490.61
References & Citations
[1]Yonggang Meng, et al. Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer. J Med Chem. 2021 Jan 28;64 (2) :925-937. |[2]Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57 (20) :8249-67.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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