Ibudilast-d7-1

Ibudilast-d7-1 is the deuterium labeled Ibudilast[1]. Ibudilast (KC-404; AV-411; MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia[2].

Product Specifications

CAS Number

1204192-90-4

Product Name Alternative

KC-404-d7-1; AV-411-d7-1; MN-166-d7-1

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

CC(C)C(C1=C2N(C=CC=C2)N=C1C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=O

Molecular Formula

C14H11D7N2O

Molecular Weight

237.35

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Mizuno T, et al. Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia. Neuropharmacology. 2004 Mar;46 (3) :404-11.