Imidafenacin (hydrochloride)

Imidafenacin hydrochloride is a potent and selective inhibitor of M3 receptors with a Kb of 0.317 nM[1].

Product Specifications

CAS Number

[893421-54-0]

Product Name Alternative

KRP-197 (hydrochloride) ; ONO-8025 (hydrochloride)

UNSPSC

12352005

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/imidafenacin-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C(N)C(C1=CC=CC=C1)(C2=CC=CC=C2)CCN3C=CN=C3C.[H]Cl

Molecular Formula

C20H22ClN3O

Molecular Weight

355.86

References & Citations

[1]Miyachi H, et al. Synthesis and antimuscarinic activity of a series of 4- (1-Imidazolyl) -2,2-diphenylbutyramides: discovery of potent and subtype-selective antimuscarinic agents. Bioorg Med Chem. 1999 Jun;7 (6) :1151-61.|[2]Yamazaki T, et al. Imidafenacin has no influence on learning in nucleus basalis of Meynert-lesioned rats. Naunyn Schmiedebergs Arch Pharmacol. 2013 Dec;386 (12) :1095-102.