Imidafenacin (hydrochloride)
Imidafenacin hydrochloride is a potent and selective inhibitor of M3 receptors with a Kb of 0.317 nM[1].
Product Specifications
CAS Number
[893421-54-0]
Product Name Alternative
KRP-197 (hydrochloride) ; ONO-8025 (hydrochloride)
UNSPSC
12352005
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/imidafenacin-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(N)C(C1=CC=CC=C1)(C2=CC=CC=C2)CCN3C=CN=C3C.[H]Cl
Molecular Formula
C20H22ClN3O
Molecular Weight
355.86
References & Citations
[1]Miyachi H, et al. Synthesis and antimuscarinic activity of a series of 4- (1-Imidazolyl) -2,2-diphenylbutyramides: discovery of potent and subtype-selective antimuscarinic agents. Bioorg Med Chem. 1999 Jun;7 (6) :1151-61.|[2]Yamazaki T, et al. Imidafenacin has no influence on learning in nucleus basalis of Meynert-lesioned rats. Naunyn Schmiedebergs Arch Pharmacol. 2013 Dec;386 (12) :1095-102.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Curated Selection
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