Aceclofenac-d4

Aceclofenac-d4 is the deuterium labeled Aceclofenac. Aceclofenac is an orally active nonsteroidal anti-inflammatory agent (NSAID), with analgesic and anti-inflammatory properties. Aceclofenac is used for the research of osteoarthritis, ankylosing spondylitis, rheumatoid arthritis[1][2].

Product Specifications

CAS Number

[2748492-20-6]

UNSPSC

12352005

Target

COX; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation; Others

Field of Research

Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

O=C(OCC(O)=O)CC1=C([2H])C([2H])=C([2H])C([2H])=C1NC2=C(Cl)C=CC=C2Cl

Molecular Formula

C16H9D4Cl2NO4

Molecular Weight

358.21

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Y Henrotin, et al. In vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators. Inflamm Res. 2001 Aug;50 (8) :391-9.|[3]E Maneiro, et al. Aceclofenac increases the synthesis of interleukin 1 receptor antagonist and decreases the production of nitric oxide in human articular chondrocytes. J Rheumatol. 2001 Dec;28 (12) :2692-9.|[4]E Maneiro, et al. Keumhan Noh, et al. Absolute bioavailability and metabolism of aceclofenac in rats. Arch Pharm Res. 2015 Jan;38 (1) :68-72.