Lercanidipine-d3 (hydrochloride)
Product Specifications
UNSPSC Description
Lercanidipine-d3 (hydrochloride) is the deuterium labeled Lercanidipine. Lercanidipine is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine has long lasting antihypertensive action and reno-protective effect[1][2][3].
Target Antigen
Calcium Channel; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling;Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Purity
98.14
Solubility
DMSO : 20 mg/mL (ultrasonic;warming)
Smiles
C(OC(CN(CCC(C1=CC=CC=C1)C2=CC=CC=C2)C([2H])([2H])[2H])(C)C)(=O)C=3C(C(C(OC)=O)=C(C)NC3C)C4=CC(N(=O)=O)=CC=C4.Cl
Molecular Weight
651.21
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Barrios, V., et al., Lercanidipine is an effective and well tolerated antihypertensive drug regardless the cardiovascular risk profile: The LAURA study. Int J Clin Pract, 2006. 60(11): p. 1364-70.|[3]Burnier, M., M. Pruijm, and G. Wuerzner, Treatment of essential hypertension with calcium channel blockers: what is the place of lercanidipine? Expert Opin Drug Metab Toxicol, 2009. 5(8): p. 981-7.|[4]Grassi G, et, al. Lercanidipine in the Management of Hypertension: An Update. J Pharmacol Pharmacother. Oct-Dec 2017;8(4):155-165.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Clinical Information
No Development Reported
CAS Number
1189954-18-4
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