Taltirelin-13C, d3

Taltirelin-13C, d3 (TA-0910-13C, d3) is 13C and deuterated labeled Taltirelin (HY-B0596) . Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release) .

Product Specifications

Product Name Alternative

TA-0910-13C, d3

UNSPSC

12352005

Target

Apoptosis; Isotope-Labeled Compounds; Thyroid Hormone Receptor

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Others; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Endocrinology; Neurological Disease

Solubility

10 mM in DMSO

Smiles

O=C(N(CCC1)[C@@H]1C(N)=O)[C@@H](NC([C@@H](NC2=O)CC(N2[13C]([2H])([2H])[2H])=O)=O)CC3=CN=CN3

Molecular Formula

C16 13CH20D3N7O5

Molecular Weight

409.42

References & Citations

[1]Thirunarayanan N, et al. Taltirelin is a superagonist at the human thyrotropin-releasing hormone receptor. Front Endocrinol (Lausanne) . 2012 Oct 9;3:120.|[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.