Cyclosporin A-13C2, d4
Cyclosporin A-13C2, d4 (Cyclosporine A-13C2, d4; Ciclosporin A-13C2, d4) is a 13C labeled Cyclosporin A. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM[2]. Cyclosporin A also inhibits CD11a/CD18 adhesion[3].
Product Specifications
Product Name Alternative
Cyclosporine A-13C2, d4; Ciclosporin A-13C2, d4; CsA-13C2, d4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Purity
95.21
Solubility
10 mM in DMSO
Smiles
Molecular Formula
C60 13C2H107D4N11O12
Molecular Weight
1208.62
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-246.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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