Nafcillin (sodium)

Nafcillin sodium, an antibiotic, is a reversible inhibitor of β-lactamase. Nafcillin sodium can be used for the research of staphylococcal infections[1][2].

Product Specifications

CAS Number

[985-16-0]

UNSPSC

12352005

Hazard Statement

H317-H334

Target

Antibiotic; Bacterial; Beta-lactamase

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/nafcillin-sodium.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H]1N(C2=O)[C@]([C@@H]2NC(C(C3=CC=CC=C3C=C4)=C4OCC)=O)([H])SC1(C)C)O[Na]

Molecular Formula

C21H21N2NaO5S

Molecular Weight

436.46

Precautions

P261-P272-P280-P284-P302+P352-P304+P340-P362+P364-P501

References & Citations

[1]Tan AK, et, al. Identification of the site of covalent attachment of nafcillin, a reversible suicide inhibitor of beta-lactamase. Biochem J. 1992 Jan 1;281 (Pt 1) (Pt 1) :191-6.|[2]Palmer DL, et, al. Bacterial wound colonization after broad-spectrum versus narrow-spectrum antibiotics. Ann Thorac Surg. 1995 Mar;59 (3) :626-31.|[3]Lawrence I. Mortin, et al. Rapid Bactericidal Activity of Daptomycin against Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Peritonitis in Mice as Measured with Bioluminescent Bacteria. Antimicrob Agents Chemother. 2007 May; 51 (5) : 1787-1794.