Homatropine

Homatropine is an orally active muscarinic acetylcholine receptor antagonist and can be used as an anticholinergic agent[1].

Product Specifications

CAS Number

[87-00-3]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/homatropine.html

Solubility

10 mM in DMSO

Smiles

O=C(C(C1=CC=CC=C1)O)O[C@H]2C[C@@H](CC3)N(C)[C@@H]3C2

Molecular Formula

C16H21NO3

Molecular Weight

275.34

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Leung, E. and F. Mitchelson, Modification by hexamethonium of the muscarinic receptors blocking activity of pancuronium and homatropine in isolated tissues of the guinea-pig. Eur J Pharmacol, 1982. 80 (1) : p. 11-7.|[2]Gilani, S.A. and L.B. Cobbin, Interaction of himbacine with carbachol at muscarinic receptors of heart and smooth muscle. Arch Int Pharmacodyn Ther, 1987. 290 (1) : p. 46-53.|[3]Cramer, M.B., L.A. Cates, and D.E. Clarke, Rectal absorption of homatropine [14C]methylbromide in the rat. J Pharm Pharmacol, 1978. 30 (5) : p. 284-6.