Benztropine

Benztropine (Benzatropine; Benzotropine) is an orally active centrally acting anticholinergic agent that can be used for Parkinson's disease research[1]. Benztropine is an anti-histamine agent and a dopamine re-uptake inhibitor. Benztropine is also a human D2 dopamine receptor allosteric antagonist. Benztropine mesylate also has anti-CSCs (cancer stem cells) effects[2].

Product Specifications

CAS Number

[86-13-5]

Product Name Alternative

Benzatropine; Benzotropine

UNSPSC

12352005

Target

Dopamine Receptor; Histamine Receptor; mAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/benztropine.html

Purity

98.1200

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN1[C@H]2CC(OC(C3=CC=CC=C3)C4=CC=CC=C4)C[C@@H]1CC2

Molecular Formula

C21H25NO

Molecular Weight

307.43

References & Citations

[1]Santosh S Kulkarni, et al. Comparative structure-activity relationships of benztropine analogues at the dopamine transporter and histamine H (1) receptors. Bioorg Med Chem. 2006 Jun 1;14 (11) :3625-34.|[2]Jihong Cui, et al. New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate. Oncotarget. 2017 Jan 3;8 (1) :1007-1022.