Lamotrigine-13C3

Lamotrigine-13C3 is the 13C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].

Product Specifications

CAS Number

[1188265-38-4]

Product Name Alternative

LTG-13C3; BW430C-13C3

UNSPSC

12352005

Hazard Statement

H301, H319, H336, H361, H362, H410

Target

Autophagy; Sodium Channel

Type

Isotope-Labeled Compounds

Related Pathways

Autophagy; Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lamotrigine-13c3.html

Solubility

10 mM in DMSO

Smiles

N[13C]1=N[13C](N)=NN=[13C]1C2=C(C(Cl)=CC=C2)Cl

Molecular Formula

C6 13C3H7Cl2N5

Molecular Weight

259.07

Precautions

H301, H319, H336, H361, H362, H410

References & Citations

[1]M J Leach, et al. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia. Sep-Oct 1986;27 (5) :490-7.|[2]Damianka P Getova, et al. A study of the effects of lamotrigine on mice using two convulsive tests. Folia Med (Plovdiv) . Apr-Jun 2011;53 (2) :57-62.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.