Buflomedil
Buflomedil, a vasodilator agent, is an orally active α1A-adrenoceptor antagonist with Kis of 4.06 µM and 6.84 µM for α1A-AR and α1B-AR, respectively. Buflomedil can be used for the study of peripheral circulatory disorders[1][2].
Product Specifications
CAS Number
55837-25-7
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/buflomedil.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(OC)C=C(OC)C=C1OC)CCCN2CCCC2
Molecular Formula
C17H25NO4
Molecular Weight
307.38
Precautions
P261-P280-P302+P352
References & Citations
[1]de Backer TL, et al. Buflomedil for intermittent claudication. Cochrane Database Syst Rev. 2013 Mar 28;2013 (3) :CD000988.|[2]Limbs International Medicinal Buflomedil (LIMB) Study Group; Leizorovicz A, Becker F. Oral buflomedil in the prevention of cardiovascular events in patients with peripheral arterial obstructive disease: a randomized, placebo-controlled, 4-year study. Circulation. 2008 Feb 12;117 (6) :816-22.|[3]Tang LM, et al. Inhibitory effect of buflomedil on prostate alpha1A adrenoceptor in the Wistar rat. Neurosci Lett. 2004 Sep 2;367 (2) :224-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
α adrenergic receptor
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