N-Boc-dolaproine-OH ((+) -phenylethylamine)
N-Boc-dolaproine-OH ((+) -phenylethylamine) is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580) . Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity[1].
Product Specifications
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Microtubule/Tubulin; Mitosis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n-boc-dolaproine-oh-plus-phenylethylamine.html
Purity
99.79
Solubility
10 mM in DMSO
Smiles
C[C@@H](N)C1=CC=CC=C1.O[C@H]([C@@H](C)C(O)=O)[C@H]2N(C(OC(C)(C)C)=O)CCC2
Molecular Formula
C21H34N2O5
Molecular Weight
394.51
Precautions
H302, H315, H319, H335
References & Citations
[1]Almeida W P, et al. An easy and stereoselective synthesis of N-Boc-dolaproine via the Baylis–Hillman reaction[J]. Tetrahedron letters, 2003, 44 (5) : 937-940.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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