Phenytoin-15N2,13C

Phenytoin-15N2,13C is the 13C and 15N labeled Phenytoin[1]. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[2][3].

Product Specifications

CAS Number

[78213-26-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Sodium Channel; Virus Protease

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

COVID-19-anti-virus

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/phenytoin-15n2-13c.html

Concentration

391.77 μM * 1.2 mL in Methanol

Purity

99.84

Solubility

10 mM in DMSO

Smiles

O=C1C(C2=CC=CC=C2)(C3=CC=CC=C3)[15NH][13C]([15NH]1)=O

Molecular Formula

C14 13CH12 15N2O2

Molecular Weight

255.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Rogawski, M.A. and W. Loscher, The neurobiology of antiepileptic drugs. Nat Rev Neurosci, 2004. 5 (7) : p. 553-64.|[3]Porter, R.J., et al., Mechanisms of action of antiseizure drugs. Handb Clin Neurol, 2012. 108: p. 663-81.|[4]Balaji, S., Medical therapy for sudden death. Pediatr Clin North Am, 2004. 51 (5) : p. 1379-87.|[5]Michaela Nelson, et al. The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. Mol Cancer. 2015 Jan 2714 (1) :13.