Phenytoin-d10

Phenytoin-d10 is the deuterium labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[1][2].

Product Specifications

CAS Number

[65854-97-9]

Product Name Alternative

5,5-Diphenylhydantoin-d10

UNSPSC

12352005

Hazard Statement

H225, H301+H311+H331, H370

Target

Isotope-Labeled Compounds; Sodium Channel; Virus Protease

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Others

Field of Research

Cancer; Neurological Disease

Purity

99.50

Solubility

10 mM in DMSO|DMSO : 50mg/mL (ultrasonic)

Smiles

O=C1C(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])(C3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])NC(N1)=O

Molecular Formula

C15H2D10N2O2

Molecular Weight

262.33

Precautions

H225, H301+H311+H331, H370

References & Citations

[4]Balaji, S., Medical therapy for sudden death. Pediatr Clin North Am, 2004. 51 (5) : p. 1379-87.|[5]Michaela Nelson, et al. The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. Mol Cancer. 2015 Jan 27;14 (1) :13.|[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Rogawski, M.A. and W. Loscher, The neurobiology of antiepileptic drugs. Nat Rev Neurosci, 2004. 5 (7) : p. 553-64.|[3]Porter, R.J., et al., Mechanisms of action of antiseizure drugs. Handb Clin Neurol, 2012. 108: p. 663-81.