Sulfadoxine-d4

Sulfadoxine-d4 is the deuterium labeled Sulfadoxine. Sulfadoxine (Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other agents, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.

Product Specifications

CAS Number

[1330266-05-1]

Product Name Alternative

Sulphadoxine-d4

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Antibiotic; Endogenous Metabolite; HIV; Parasite

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Purity

98.0

Solubility

10 mM in DMSO|DMSO : ≥ 100mg/mL|H2O : 0.1mg/mL (ultrasonic)

Smiles

O=S(C1=C([2H])C([2H])=C(N)C([2H])=C1[2H])(NC2=NC=NC(OC)=C2OC)=O

Molecular Formula

C12H10D4N4O4S

Molecular Weight

314.35

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]D'Alessandro S, et al. The Use of Antimalarial Drugs against Viral Infection. Microorganisms. 2020 Jan 8;8 (1) . pii: E85.|[3]http://www.malaria-ipca.com/sulphadoxine_pyrimethamine.html|[4]http://en.wikipedia.org/wiki/Sulfadoxine/pyrimethamine