Mycophenolic acid-13C17

Mycophenolic acid-13C17 (Mycophenolate-13C17) is the 13C labeled Mycophenolic acid (HY-B0421) . Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.

Product Specifications

CAS Number

[1202866-92-9]

Product Name Alternative

Mycophenolate-13C17

UNSPSC

12352005

Hazard Statement

H225-H302+H312+H332-H319

Target

Flavivirus; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mycophenolic-acid-13c17.html

Solubility

10 mM in DMSO

Smiles

[13CH3][13C]1=[13C]2[13C]([13C](O[13CH2]2)=O)=[13C]([13C]([13CH2]/[13CH]=[13C]([13CH3])/[13CH2][13CH2][13C](O)=O)=[13C]1O[13CH3])O

Molecular Formula

13C17H20O6

Molecular Weight

337.21

Precautions

P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P330-P362+P364-P370+P378-P403+P235-P501

References & Citations

[1]Sophie Domhan, et al. Molecular mechanisms of the antiangiogenic and antitumor effects of mycophenolic acid. Mol Cancer Ther. 2008 Jun;7 (6) :1656-68.|[2]Stephen R Welch, et al. Screening and Identification of Lujo Virus Inhibitors Using a Recombinant Reporter Virus Platform. Viruses. 2021 Jun 28;13 (7) :1255.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-220.