What is the catalog number for Manidipine-d4?

The catalog number for Manidipine-d4 is HY-B0419S.

What sizes are available for Manidipine-d4?

Manidipine-d4 is available in the following size(s): 1 mg.

Is Manidipine-d4 in stock?

Manidipine-d4 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Manidipine-d4?

Manidipine-d4 is manufactured by QuantiMol.

What is the estimated delivery time for Manidipine-d4?

Estimated delivery time for Manidipine-d4 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Manidipine-d4?

The safety data sheet for Manidipine-d4 is available here: http://file.medchemexpress.com/batch_PDF/HY-B0419S/.

Manidipine-d4

Manidipine-d4 is the deuterium labeled Manidipine. Manidipine is an orally active calcium channel antagonist. Manidipine regulates the expression of cytokines (IL-1β, IL-6). Manidipine has a hypotensive effect. Manidipine can be used in the study of cardiovascular diseases (such as hypertension, myocardial ischemia-reperfusion injury, ventricular hypertrophy), kidney diseases (such as glomerular diseases), and epilepsy[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

1189656-59-4

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Calcium Channel; Interleukin Related; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Solubility

10 mM in DMSO

Smiles

C(OC(C(N1CCN(C(C2=CC=CC=C2)C3=CC=CC=C3)CC1)([2H])[2H])([2H])[2H])(=O)C=4C(C(C(OC)=O)=C(C)NC4C)C5=CC(N(=O)=O)=CC=C5

Molecular Formula

C35H34D4N4O6

Molecular Weight

614.72

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Roth M, et al. Manidipine regulates the transcription of cytokine genes. Proc Natl Acad Sci U S A. 1992 May 1;89 (9) :4071-5.|[2]Huang S, et al. Manidipine inhibits endothelin-1-induced [Ca2+]i signaling but potentiates endothelin's effect on c-fos and c-jun induction in vascular smooth muscle and glomerular mesangial cells. Am Heart J. 1993 Feb;125 (2 Pt 2) :589-97.|[3]Costa S, et al. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Pharmacol Res. 2010 Sep;62 (3) :265-70.|[4]Yoshiyama M, et al. Effect of manidipine hydrochloride, a calcium antagonist, on isoproterenol-induced left ventricular hypertrophy. Jpn Circ J. 1998 Jan;62 (1) :47-52.|[5]Tojo A, et al. Effects of manidipine hydrochloride on the renal microcirculation in spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1992 Dec;20 (6) :895-9.|[6]Rossoni G, et al. Combined simvastatin-manidipine protect against ischemia-reperfusion injury in isolated hearts from normocholesterolemic rats. Eur J Pharmacol. 2008 Jun 10;587 (1-3) :224-30.|[7]Haraguchi K, et al. Catalepsy induced by manidipine, a calcium channel blocker, in mice. J Pharm Pharmacol. 1996 Apr;48 (4) :429-32.|[8]Souza C N S, et al. 074— (SOA0068) Anticonvulsant activity of acute treatment with manidipine in pentylenetetrazole-and pilocarpine-induced seizure models in mice. Epilepsy & Behavior, 2014, 38: 214.