Amantadine (sulfate)

Amantadine (1-Adamantanamine) sulfate is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine sulfate inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine sulfate also has anti-orthopoxvirus and anticancer activity. Amantadine sulfate can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[1][2][3][4][5][6].

Product Specifications

CAS Number

[31377-23-8]

Product Name Alternative

1-Adamantanamine (sulfate) ; 1-Aminoadamantane (sulfate)

UNSPSC

12352211

Hazard Statement

H315-H319

Target

Apoptosis; Bcl-2 Family; CDK; Influenza Virus; Orthopoxvirus; SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/amantadine-sulfate.html

Solubility

10 mM in DMSO

Smiles

NC1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1.O=S(O)(O)=O.[1/2]

Molecular Formula

C10H17N.1/2H2O4S

Molecular Weight

200.18

Precautions

P264-P280-P302+P352-P362+P364

References & Citations

[1]Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9 (3) :195-200.|[2]Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78 (14) :1096-1099.|[3]Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57 (1-2) :41-52. |[4]Fink K, et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 24;13 (4) :539. |[5]Zhang J, et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct;121 (4) :773-85. |[6]Lan Z, et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med. 2015;36 (3) :904-910.