Tiopronin-d3

Tiopronin-d3 is the deuterium labeled Tiopronin. Tiopronin is a diffusible antioxidant, an antidote to heavy metal poisoning and a radioprotective agent. Tiopronin can control the rate of cystine precipitation and excretion and has the potential for cystinuria, rheumatoid arthritis and hepatic disorders[1][2].

Product Specifications

CAS Number

[1189700-74-0]

UNSPSC

12352211

Hazard Statement

H302

Target

Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Purity

99.42

Solubility

10 mM in DMSO

Smiles

OC(CNC(C(S)C([2H])([2H])[2H])=O)=O

Molecular Formula

C5H6D3NO3S

Molecular Weight

166.21

Precautions

H302

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Pu Zhang, et al. Detection of tiopronin in body fluids and pharmaceutical products using red-emissive DNA-stabilized silver nanoclusters as a fluorescent probe. Mikrochim Acta. 2019 Aug 8;186 (9) :609.|[3]Soohwan Yum, et al. N- (2-Mercaptopropionyl) -glycine, a diffusible antioxidant, activates HIF-1 by inhibiting HIF prolyl hydroxylase-2: implication in amelioration of rat colitis by the antioxidant. Biochem Biophys Res Commun. 2014 Jan 17;443 (3) :1008-13.