Nimesulide-d5
Product Specifications
UNSPSC Description
Nimesulide-d5 is a deuterium labeled Nimesulide. Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties[1][2].
Target Antigen
COX; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Immunology/Inflammation;Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
CS(=O)(NC1=CC=C([N+]([O-])=O)C=C1OC2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])=O
Molecular Weight
313.34
References & Citations
[1]Vago T, et al. Effect of nimesulide action time dependence on selectivity towards prostaglandin G/H synthase/cyclooxygenase activity. Arzneimittelforschung. 1995 Oct;45(10):1096-8.|[2]Werner MF, et al. Nimesulide-induced antipyresis in rats involves both cyclooxygenase-dependent and independent mechanisms. Eur J Pharmacol. 2006 Aug 14;543(1-3):181-9.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
CAS Number
1330180-22-7
Curated Selection
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