Lacidipine-13C8
Product Specifications
UNSPSC Description
Lacidipine-13C8 is the deuterium labeled Lacidipine[1]. Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI)[2][3].
Target Antigen
Apoptosis; Calcium Channel; Caspase; Reactive Oxygen Species
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis;Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling;NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/lacidipine-13c8.html
Solubility
10 mM in DMSO
Smiles
CCO[13C]([13C]1=[13C](N[13C]([13CH3])=[13C](C1C2=C(/C=C/C(OC(C)(C)C)=O)C=CC=C2)[13C](OCC)=O)[13CH3])=O
Molecular Weight
463.48
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Zhang A, et al. Lacidipine attenuates apoptosis via a caspase-3 dependent pathway in human kidney cells. Cell Physiol Biochem. 2013;32(4):1040-9. |[3]Cristofori P, et al. The calcium-channel blocker lacidipine reduces the development of atherosclerotic lesions in the apoE-deficient mouse. J Hypertens. 2000 Oct;18(10):1429-36.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B0347S1/Lacidipine-13C8-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B0347S1/
Clinical Information
No Development Reported
CAS Number
1261432-01-2
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