Sulfisoxazole (diethanolamine)

Sulfisoxazole (Sulfafurazole) diethanolamine is an endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole diethanolamine is a sulfonamide antibacterial with an oxazole substituent. Sulfisoxazole diethanolamine inhibits breast cancer exosome release by targeting endothelin receptor A[1][2].

Product Specifications

CAS Number

[4299-60-9]

Product Name Alternative

Sulfafurazole (diethanolamine)

UNSPSC

12352005

Target

Antibiotic; Bacterial; Endothelin Receptor

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Infection; Endocrinology

Assay Protocol

https://www.medchemexpress.com/sulfisoxazole-diethanolamine.html

Solubility

10 mM in DMSO

Smiles

O=S(C1=CC=C(N)C=C1)(NC2=C(C)C(C)=NO2)=O.OCCNCCO

Molecular Formula

C15H24N4O5S

Molecular Weight

372.44

References & Citations

[1]Chan, M.F., et al., Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem Biophys Res Commun, 1994. 201 (1) : p. 228-34.|[2]Im EJ, et al. Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A. Nat Commun. 2019 Mar 27;10 (1) :1387.