Dipyridamole-d16
Dipyridamole-d16 is the deuterium labeled Dipyridamole. Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.
Product Specifications
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
OC([2H])(C([2H])(N(C1=NC2=C(C(N3CCCCC3)=N1)N=C(N=C2N4CCCCC4)N(C([2H])(C([2H])(O)[2H])[2H])C([2H])(C([2H])(O)[2H])[2H])C([2H])(C([2H])(O)[2H])[2H])[2H])[2H]
Molecular Formula
C24H24D16N8O4
Molecular Weight
520.72
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Klabunde, R.E., Dipyridamole inhibition of adenosine metabolism in human blood. Eur J Pharmacol, 1983. 93 (1-2) : p. 21-6.|[3]Best, L.C., et al., Mode of action of dipyridamole on human platelets. Thromb Res, 1979. 16 (3-4) : p. 367-79.|[4]Aktas, B., et al., Dipyridamole enhances NO/cGMP-mediated vasodilator-stimulated phosphoprotein phosphorylation and signaling in human platelets: in vitro and in vivo/ex vivo studies. Stroke, 2003. 34 (3) : p. 764-9.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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