Clemastine

Clemastine (HS-592) is a potent and orally active histamine receptor H1 antagonist. Clemastine is an antihistamine mainly used for relieving symptoms of allergic reactions primarily by competing with histamine to bind H1 receptors. Anti-inflammatory effects[1][2].

Product Specifications

CAS Number

[15686-51-8]

Product Name Alternative

HS-592; Meclastine

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/clemastine.html

Purity

98.4100

Solubility

10 mM in DMSO

Smiles

CN1[C@@H](CCO[C@](C2=CC=CC=C2)(C3=CC=C(Cl)C=C3)C)CCC1

Molecular Formula

C21H26ClNO

Molecular Weight

343.89

References & Citations

[1]Clemastine. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD) : National Institute of Diabetes and Digestive and Kidney Diseases; January 16, 2017.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

H1 Receptor

Citation 01

Methods Mol Biol. 2023:2683:103-111.|Neurosci Bull. 2025 Jul 17.|Biochem Biophys Res Commun. 2020 Feb 19;522 (4) :862-868.|Br J Pharmacol. 2025 Jun;182 (12) :2730-2753.|Cell Prolif. 2021 Jan;54 (1) :e12953.|Exp Neurol. 2024 Dec 3:115086.|Microbiol Spectr. 2022 Apr 27;10 (2) :e0054121.|Prog Neuropsychopharmacol Biol Psychiatry. 2024 Feb 8:129:110901.|Redox Biol. 2025 Sep 20:87:103875.|Viruses. 2021 Jun 28;13 (7) :1255.