Acetylcholine-d9 (chloride)

Acetylcholine-d9 (chloride) is the deuterium labeled Acetylcholine chloride. Acetylcholine chloride (ACh chloride), a neurotransmitter, is a potent cholinergic agonist. Acetylcholine chloride is a modulator of the activity of dopaminergic (DAergic) neurons through the stimulation of nicotinic acetylcholine receptors (nAChRs) [1][2]. Acetylcholine chloride inhibits p53 mutant peptide aggregation in vitro[5].

Product Specifications

CAS Number

[344298-95-9]

Product Name Alternative

ACh-d9 (chloride)

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Calcium Channel; Endogenous Metabolite; nAChR

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Neurological Disease; Cancer

Purity

99.0

Solubility

10 mM in DMSO|DMSO : 62.5mg/mL (ultrasonic) |H2O : 100mg/mL (ultrasonic)

Smiles

CC(OCC[N+](C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O.[Cl-]

Molecular Formula

C7H7D9ClNO2

Molecular Weight

190.72

Precautions

H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Prashant Tiwari, et al. Basic and modern concepts on cholinergic receptor: A review. Asian Pac J Trop Dis. 2013 Oct;3 (5) : 413-420.|[3]A Young, et al. Diarrhoea of famine and malnutrition--investigations using a rat model. 2--Ileal hypersecretion induced by starvation. Gut. 1990 Feb;31 (2) :162-9.|[4]Xia Lei, et al. Effects of acetylcholine chloride on intracellular calcium concentration of cultured sweat gland epithelial cells. Arch Dermatol Res. 2008 Aug;300 (7) :335-41.|[5]P F Zabrodskii, et al. Effect of acetylcholine on mortality of mice from sepsis and proinflammatory cytokine production. Bull Exp Biol Med. 2011 Jan;150 (3) :340-2.|[6]Zhaolin Chen, et al. Inhibition of p53 Mutant Peptide Aggregation In Vitro by Cationic Osmolyte Acetylcholine Chloride. Protein Pept Lett. 2017;24 (4) :353-357.