Threo-Chloramphenicol-d6
Threo-Chloramphenicol-d6 is the deuterium labeled Chloramphenicol[1]. Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research[2][3][4].
Product Specifications
UNSPSC
12352005
Target
Akt; Antibiotic; Apoptosis; Autophagy; Bacterial; Beclin1; HIF/HIF Prolyl-Hydroxylase; JNK; MMP; VEGFR
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Autophagy; MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
O=C(N[C@H](C([2H])O)[C@@](O)([2H])C1=C([2H])C([2H])=C([N+]([O-])=O)C([2H])=C1[2H])C(Cl)Cl
Molecular Formula
C11H6D6Cl2N2O5
Molecular Weight
329.17
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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