6-Aminocaproic acid-d6

6-Aminocaproic acid-d6 is deuterium labeled 6-Aminocaproic acid. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].

Product Specifications

CAS Number

[1228656-08-3]

Product Name Alternative

EACA-d6; Epsilon-Amino-n-caproic acid-d6; 6-Aminohexanoic acid-d6

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Purity

99.93

Solubility

DMSO : < 1 mg/mL|H2O : ≥ 50mg/mL

Smiles

O=C(O)CC([2H])([2H])C([2H])([2H])C([2H])([2H])CN

Molecular Formula

C6H7D6NO2

Molecular Weight

137.21

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Brown JC, et, al. Effect of aminocaproic acid on clot strength and clot lysis of canine blood determined by use of an in vitro model of hyperfibrinolysis. Am J Vet Res. 2016 Nov;77 (11) :1258-1265.|[3]Griffin JD, et, al. Epsilon-aminocaproic acid (EACA) . Semin Thromb Hemost. Summer 1978;5 (1) :27-40.|[4]Kaye S, et, al. EFFECT OF ε-AMINOCAPROIC ACID ON FIBRINOLYSIS IN PLASMA OF ASIAN ELEPHANTS (ELEPHAS MAXIMUS) . J Zoo Wildl Med. 2016 Jun;47 (2) :397-404.