Riluzole-13C,15N2

Riluzole-13C,15N2 is the 13C and 15N labeled Riluzole[1]. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM[2][3].

Product Specifications

CAS Number

[1215552-03-6]

Product Name Alternative

PK 26124-13C,15N2

UNSPSC

12352005

Hazard Statement

H300

Target

GABA Receptor; Sodium Channel

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/riluzole-13c-15n2.html

Purity

99.90

Solubility

10 mM in DMSO

Smiles

[15NH2][13C]1=[15N]C2=CC=C(OC(F)(F)F)C=C2S1

Molecular Formula

C7 13CH5F3 15N2OS

Molecular Weight

237.18

Precautions

H300

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]He Y, et al. Neuroprotective agent riluzole potentiates postsynaptic GABA (A) receptor function. Neuropharmacology. 2002 Feb;42 (2) :199-209.|[3]Thompson JM, et al. Small-conductance calcium-activated potassium (SK) channels in the amygdala mediate pain-inhibiting effects of clinically available riluzole in a rat model of arthritis pain. Mol Pain. 2015 Aug 2811:51.