Irbesartan (hydrochloride)

Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB) . Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease[1].

Product Specifications

CAS Number

[329055-23-4]

Product Name Alternative

SR-47436 (hydrochloride) ; BMS-186295 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Angiotensin Receptor; Apoptosis

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/irbesartan-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C1N(CC2=CC=C(C3=C(C4=NN=NN4)C=CC=C3)C=C2)C(CCCC)=NC15CCCC5.[H]Cl

Molecular Formula

C25H29ClN6O

Molecular Weight

464.99

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Yong Zhong, et al. Irbesartan may relieve renal injury by suppressing Th22 cells chemotaxis and infiltration in Ang II-induced hypertension. Int Immunopharmacol